Disable Genesis Page Layouts

Disable content-sidebar layout:

genesis_unregister_layout( 'content-sidebar' );

Disable sidebar-content layout:

genesis_unregister_layout( 'sidebar-content' );

Disable content-sidebar-sidebar layout:

genesis_unregister_layout( 'content-sidebar-sidebar' );

Disable sidebar-sidebar-content layout:

genesis_unregister_layout( 'sidebar-sidebar-content' );

Disable sidebar-content-sidebar layout:

genesis_unregister_layout( 'sidebar-content-sidebar' );

Disable full-width layout:

genesis_unregister_layout( 'full-width-content' );

Disable all layouts

genesis_unregister_layout( 'content-sidebar' );
genesis_unregister_layout( 'sidebar-content' );
genesis_unregister_layout( 'content-sidebar-sidebar' );
genesis_unregister_layout( 'sidebar-sidebar-content' );
genesis_unregister_layout( 'sidebar-content-sidebar' );
genesis_unregister_layout( 'full-width-content' );